TITLE:
Synthesis, Characterization and Antimicrobial Studies of Co(II), Ni(II), Cu(II) and Zn(II) Complexes of (E)-2-(4-Dimethylbenzydimino)-Glycylglycine, (Glygly-DAB) a Schiff Base Derived from 4-Dimethylaminobenzaldehyde and Glycylglycine
AUTHORS:
Maurice Kuate, Mariam Asseng Conde, Katia N. Nchimi, Awawou G. Paboudam, Sally-Judith E. Ntum, Peter T. Ndifon
KEYWORDS:
Schiff Base Ligand, Glycylglycine, Complexes, Antimicrobial Activities, Spectroscopy
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.8 No.3,
August
7,
2018
ABSTRACT: A
tridentate Schiff base ligand, (E)-2-(4-dimethylbenzydimino) glycylglycine (glygly-DAB), derived from the condensation
of 4-Dimethylaminobenzaldehyde (DAB) and
glycylglycine (glygly) together with its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized
and characterized using various physico-chemical methods including C,H,N elemental
analysis, melting point determination, molar conductivity measurement, IR, 1H NMR
and UV-Vis. The ligand and metal complexes were screened in vitro for antimicrobial and antifungal activities on four
bacterial strains (Staphylococcus aureus, Escherichia coli, Salmonella thyphi and Pseudomonas aeruginosa) and two fungal
strains (Candida albicans and Cryptococcus neoformans). glygly-DAB showed remarkable
antifungal activities on all the fungal strains and antibacterial activities on
one bacterial strain.