TITLE:
Oxidative Stress and Dyslipidemia as Indicators of Pathogenesis of Preeclampsia in Pregnant Sudanese Women
AUTHORS:
Hafiz Ahmed Hobiel, Hani Yousif Zaki Tadros
KEYWORDS:
Preeclampsia, Oxidative Stress, Total Antioxidant Capacity, Nitric Oxide, Dyslipidemia
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.6 No.7,
July
27,
2018
ABSTRACT: Background: Preeclampsia
(PE) still ranks as one of obstetrics major problems and is still a serious threat, mainly in underdeveloped countries
where its incidence and mortality rates are higher and is a major cause
of preterm birth and intra-uterine growth restriction. Aim: To evaluate
the role of oxidative stress and dyslipidemia as indicators of pathogenesis and
risks of preeclampsia in pregnant Sudanese women attending Wad-Medani
Obstetrics and Gynecology Teaching Hospital. Material and Method: This was a cross-sectional (case-control) study
carried out in preeclamptic pregnant Sudanese women attending Wad-Medani
Obstetrics and Gynecology Teaching Hospital. A total of 208 pregnant women were enrolled in the study, 111 patients and 97 women with normal pregnancy as
controls; pregnant women suffering from any systemic or
endocrine disorder were excluded. We compared the serum levels of total cholesterol, LDL-cholesterol, HDL-cholesterol,
triglycerides, nitric oxide, and total antioxidant capacity between
preeclamptic and controls. Result and Conclusion: Pregnant women with
increase in BMI have a higher chance of developing PE. Low level of
high-density lipoprotein cholesterol and high level of low-density lipoprotein
cholesterol define that dyslipidemia increases the
risk of PE. Decreased levels of NO and TAC might reflect the
oxidative stress and likely contribute to the pathophysiological mechanisms of
PE.