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Ezell, S.J., Li, H., Xu, H., Zhang, X., Gurpinar, E., Zhang, X., Rayburn, E.R., Sommers, C.I., Yang, X., Velu, S.E., Wang, W. and Zhang, R. (2010) Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent. Marine Drugs, 8, 2129-2141.
https://doi.org/10.3390/md8072129

has been cited by the following article:

• TITLE: Theoretical Study by Density Functional Theory Method (DFT) of Stability, Tautomerism, Reactivity and Prediction of Acidity of Quinolein-4-One Derivatives

  AUTHORS: Affoué Lucie Bédé, Amon Benjamine Assoma, Kicho Denis Yapo, Mamadou Guy-Richard Koné, Soleymane Koné, Mawa Koné, Boka Robert N’Guessan, El-Hadji Sawaliho Bamba

  KEYWORDS: Quinolein-4-One, Tautomers, Equilibrium Constants, Global Descriptors, Dual Descriptors

  JOURNAL NAME: Computational Chemistry, Vol.6 No.3, July 25, 2018

  ABSTRACT: A theoretical study of the reactivity of quinoline-4-one derivatives is undertaken in order to understand the involved mechanisms. The calculations were carried out in gas phase and in N, N-Dimethylformamide (DMF) solution. The Density Functional Theory (DFT) with B3LYP functional associated to 6-311G (d) and 6-311+G (d) bases is used to perform these calculations. The results of the thermodynamic parameters showed that there is an equilibrium relation between the different tautomers. This equilibrium can be used to explain the failure to obtain tetrahydroquinoline from 5,8-dimethoxy-quinolin-4-one. Reactivity analysis from Frontier Molecular Orbitals theory and Fukui function calculations revealed that ketone forms are less reactive than enol ones. The methoxyl substituent decreases the acidity of the nitrogen and oxygen atoms of quinolin-4-one while the bromine increases the acidity of the same sites. These results foresee that nitrogen deprotonation in the case of the brominated compound is easier than in the case of methoxylated ones.