TITLE:
Electroencephalographic Findings after Eslicarbazepine Therapy in Focal Epileptic Syndrome Patients
AUTHORS:
Gabriel Salazar, Marta Fragoso, Javier Codas
KEYWORDS:
EEG, Focal Epilepsy, Anti-Epileptic Drugs
JOURNAL NAME:
World Journal of Neuroscience,
Vol.8 No.3,
July
23,
2018
ABSTRACT: The efficacy and the tolerance of the AEDs have been extensibly studied
in the past, however the effects of them on the EEG activity of epileptic
patients have been scarcely studied. Eslicarbazepine is a third generation blocker-sodium channels AED associated with a high
reduction in the rate of partial seizures in epileptic patients. We designed an
open label, non control study to determine the effects of Eslicarbazepine on the EEG activity of EP with focal seizures in a
12-week follow up. The EP with focal paroxystical activity enrolled in this
study showed a statistical significant reduction in the rate of monthly
seizures when Eslicarbazepine 800 mgs was added to a previous AED compared to those patients who only
received an increase of the AED in monotherapy, concomitantly, EP treated with ESL
added to a previous AED showed a statistically significant reduction in the
mean occipital frequency and voltage amplitude in the central and parietal
regions in the twelfth-week EEG compared to the control group.