TITLE:
Updating Genetics Polymorphisms of Non-Syndromic Clefts Lip-Palates
AUTHORS:
Amine Rafik, Sellama Nadifi
KEYWORDS:
Cleft Lip, Cleft Palate, Cleft Lip and/or Cleft Palate, Non-Syndromic, Genetics
JOURNAL NAME:
American Journal of Molecular Biology,
Vol.8 No.3,
July
13,
2018
ABSTRACT: Introduction: Non-Syndromic Clefts Lip-Palates (NSCLP/CP) are most common congenital malformation in the world, with very important psychic and
social impact. Formation of NSCLP/CP arises from the interaction of
environmental and genetic factors. This paper provides a review of recent
progress in defining the genetic causes of NSCLP. Methods: A literature
review was conducted on the Medline data by searching for the following
keywords: genes, non-syndromic cleft lip-palate, and genetics of clefts lip-palates, until January 2018. Results: Various genes are identified in different population and country, with the
study using case parent’s trio. The aim of this study contributes to review
relative gene which has been identify in non-syndromic cleft lip and palate, and to help to have a better understanding of
the inheritance pattern of this pathology and the prevention of genetic
disease. Conclusion: Although three major genes have been confirmed, the
genetic research is necessary to provide an understanding of the
pathophysiology of the clefts lip-palates.