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Li, J., Chen, Q., Luo, X., Hong, J., Pan, K., Lin, X., Liu, X., Zhou, L., Wang, H., Xu, Y., Li, H. and Duan, C. (2015) Neutrophil-to-Lymphocyte Ratio Positively Correlates to Age in Healthy Population. Journal of Clinical Laboratory Analysis, 29, 437-443.
https://doi.org/10.1002/jcla.21791

has been cited by the following article:

• TITLE: Is Neutrophil-to-Lymphocyte Ratio a Prediction Marker for Success of Immunotherapy? Preliminary Results

  AUTHORS: Noam Asna, Ornit Cohen, Ron Batash, Asaf Sigron, Tatiana Harkovski, Moshe Schaffer

  KEYWORDS: Neutrophil-to-Lymphocyteratio (NLR), Cancer Immunotherapy, Biomarker, Cancer Treatment, Chemotherapy

  JOURNAL NAME: Open Journal of Immunology, Vol.8 No.2, June 29, 2018

  ABSTRACT: Background: Cancer immunotherapy treatments enhance the cancer treatment approach. The neutrophil-to-lymphocyteratio (NLR) has been associated with cancer prognosis, affecting progression, chemosensitivity, radiosensitivity and toxicity. Patients and Methods: Ten patients (nine males, one female), aged 68 ± 10 years, were included in this study. Six patients had squamous cell carcinoma of the lungs and two had adenocarcinoma of the lungs. One patient suffered from limb soft tissue sarcoma and one had renal cell carcinoma. All patients had metastatic disease and were pretreated with chemotherapy or biologic agents. The rationale of testing NLR was to compare it to the clinical response of the patients assessed by RECIST criteria using computerized tomography (CT) scans. Results: In regression analysis, older patients were found to respond better to immunotherapy treatment than younger patients. NLR was 4.26 ± 2.25 (p 0.01) in the older patients group and 2.84 ± 0.90 (p 0.01) in the younger patients group. No difference in response according to tumor type (p = 0.479) was observed. Conclusion: We provide preliminary evidence demonstrating that low NLR helps in understanding the value of the underlying immune system in expecting a good outcome to immune treatment. The NLR is a simple and available biomarker, easy to apply in clinical practice.