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Soler, A.P., Miller, R.D., Laughlin, K.V., Carp, N.Z., Klurfeld, D.M. and Mullin, J.M. (1999) Increased Tight Junctional Permeability Is Associated with the Development of Colon Cancer. Carcinogenesis, 20, 1425-1431.
https://doi.org/10.1093/carcin/20.8.1425

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• TITLE: Histopathological Investigation of the Stomach of Rats Fed a 60% Genetically Modified Corn Diet

  AUTHORS: Irena M. Zdziarski, Judy A. Carman, John W. Edwards

  KEYWORDS: Genetically Modified Corn, Rat Feeding Study, Long-Term Feeding Study, Histopathology, Stomach

  JOURNAL NAME: Food and Nutrition Sciences, Vol.9 No.6, June 29, 2018

  ABSTRACT: Genetic modification (GM) represents new opportunities for enhanced crop features such as improved insect resistance and herbicide tolerance. The technology allows for cross-species alterations, therefore potentially allowing a vast array of novel traits. Many GM crops have been developed and approved for human and animal consumption. The present study investigated a triple-stacked GM corn variety containing modifications for insect resistance (via cry1Ab and cry3Bb1 genes) and herbicide tolerance (via an EPSPS gene), which was fed to rats for six months. The study investigated the mucosa of the stomach. Alterations to tight junction apposition, gland dilatations with epithelial elongation and dysplasia in the GM-fed rats were observed. These results indicate that GM-corn may have an effect on rat stomach mucosa, which may have health implications.