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Schlicher, R.K., Radhakrishna, H., Tolentino, T.P., Apkarian, R.P., Zarnitsyn, V., Prausnitz, M.R. (2006) Mechanism of intracellular delivery by acoustic cavitation. Ultrasound Med. Biol. 32, 915-924.

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• TITLE: Producing single microbubbles with controlled size using microfiber

  AUTHORS: Shinji Deguchi, Satoshi Takahashi, Syuhei Tanimura, Hidenori Hiraki

  KEYWORDS: Microbubble; Nanobubble; Carbon Fiber; Glass Fiber; Infrared Laser; Drug Delivery System

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.2 No.5, October 13, 2011

  ABSTRACT: Microbubble-mediated pore formation in sonoporation includes a combination of complex processes such as collision or coalescence of translating or collapsing microbubbles with vascular cells. Although understanding the pore formation mechanisms may improve drug delivery efficiency, their details are still poorly understood. In the present study, we describe an experimental model that produces single air bubbles with controllable size. A carbon microfiber in liquids is illuminated by an infrared laser to produce individual bubbles having size comparable to that of the microfiber. The microbubbles can be physically isolated from the fiber for placing at arbitrary positions in the liquids. The lifetime of the bubbles is several tens of minutes depending on the intensity of the laser used. The preparation of the controllable air bubbles may be useful in future investigations of ultrasound-mediated microbubble–cell interactions.