TITLE:
Favorable Reproducibility of Ki-67-Labeling Index between Core Needle Biopsy and Surgical Materials in Mammary Carcinoma: Reproducibility Influenced by Hot Spots, a High Ki-67 Labeling Index, and the Total Length of Biopsy Material
AUTHORS:
Kanako Ogura, Toshiharu Matsumoto, Asumi Sakaguchi, Hiroko Onagi, Ayako Ura, Taijiro Kosaka, Toshiaki Kitabatake, Kuniaki Kojima, Toshio Morizane
KEYWORDS:
Ki-67, Core-Needle Biopsy, Breast, Invasive Carcinoma, Hot Spots
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.8 No.7,
June
27,
2018
ABSTRACT: Aims: The reproducibility of Ki-67
between core-needle biopsies and surgical materials has not been well
documented in the literature, although the concordance affects the utility of
the Ki-67 labeling index based on the core-needle biopsy materials, which
indicates the need for preoperative chemotherapy. The aim of this study was to reveal
the reproducibility of Ki-67 between both materials and the cause of
discrepancies. Methods and Results: We analyzed 137 cases of
invasive carcinoma of the breast and the compared Ki-67-labeling index between
core-needle biopsy and surgical materials. The Ki-67-labeling index of biopsy and surgical
specimens ranged from 1% to 85%
(median: 13%) and 1% to 80%
(median: 12%), respectively. The discrepancy of Ki-67-labeling ranged from 0% to 55% (median: 4%) and
could be calculated by the tumor size, hot spots of surgical materials, a high
Ki-67-labeling index based on the core-needle biopsy materials, and the total
length of core needles, respectively. Conclusions: The
concordance rate of the Ki-67-labeling index between core-needle biopsies and
surgical materials was favorable, so we can use each Ki-67-labeling index of
core-needle biopsies as a marker for preoperative chemotherapy. Factors
affecting the index discrepancy were hot spots, a high Ki-67-labeling index,
and the total length of biopsy material. Judgements on the subtypes and
clinical procedures of invasive breast carcinoma could be made comprehensively
based on not only the Ki-67-labeling index but also the existence of hot spots
and histological grade.