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Branson, H.N., Hermann, D., Bachelor, K.W., Lee, F.W., James, M.K. and Frye, S.V. (1997) Unique Preclinical Characteristics of GG745, a Potent Dual Inhibitor of 5 Alpha Reductase. Journal of Pharmacology and Experimental Therapeutics, 282, 1496-1502.

has been cited by the following article:

• TITLE: Pre-Androgen Ablation Prostate Cancer Patients Who Bleed Do Well with 5 Alpha Reductase Inhibitors

  AUTHORS: Vitalis Obisike Ofuru, Christopher Chinedu Obiorah

  KEYWORDS: Prostate Cancer, Bleeding, 5-Alpha Reductase Inhibitors

  JOURNAL NAME: Open Journal of Urology, Vol.8 No.6, June 25, 2018

  ABSTRACT: Background: Patients with gross haematuria are sometimes found to have prostate cancer after clinical evaluation. The treatment of such haematuria could be very challenging. Use of a 5 alpha reductase inhibitor like dutasteride has been found helpful in bleeding prostate cancer patients if they have not undergone hormonal manipulation before they developed haematuria. Patients and Method: 26 patients with gross haematuria of prostatic origin who had histologic confirmation of adenocarcinoma of the prostate but who have not had chemical or surgical castration were randomized to receive daily dutasteride in addition to vigorous saline irrigation and antibiotics on one arm and vigorous saline irrigation and antibiotics only as control on the other arm. The time taken before haematuria resolved and the amount of irrigation fluid used were noted. Statistical analysis was done using SPSS. Student’s t-test and Kaplan Meier survival analysis were used to test various variables at 0.5 significant levels. Results: Of the 26 patients 12(46.2%) received 0.5 mg oral dutasteride in addition to saline irrigation while 14 (53.8%) received saline irrigation only. Haematuria stopped in all of 12 (100%) patients on dutasteride arm but on 12 (85.7%) of the 14 patients on the control arm. It took significantly shorter time and lesser volume of irrigation fluid before haematuria resolved in those treated with dutasteride than in those on the control arm. Conclusion: Dutasteride is effective in the control of acute haematuria in pre-androgen ablation prostate cancer patients.