Article citationsMore>>

Pett, J.P., Korencic, A., Wesener, F., Kramer, A. and Herzel, H. (2016) Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator. PLOS Computational Biology, 12, e1005266.
https://doi.org/10.1371/journal.pcbi.1005266

has been cited by the following article:

• TITLE: Hopf Bifurcation Analysis of the Repressilator Model

  AUTHORS: Anael Verdugo

  KEYWORDS: Hopf Bifurcation, Repressilator, Center Manifold Analysis

  JOURNAL NAME: American Journal of Computational Mathematics, Vol.8 No.2, June 15, 2018

  ABSTRACT: The repressilator is a genetic network that exhibits oscillations. The net-work is formed of three genes, each of which represses each other cyclically, creating a negative feedback loop with nonlinear interactions. In this work we present a computational bifurcation analysis of the mathematical model of the repressilator. We show that the steady state undergoes a transition from stable to unstable giving rise to a stable limit-cycle in a Hopf bifurcation. The nonlinear analysis involves a center manifold reduction on the six-dimensional system, which yields closed form expressions for the frequency and amplitude of the oscillation born at the Hopf. A parameter study then shows how the dynamics of the system are influenced for different parameter values and their associated biological significance.