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Voigt, F., Goecke, T.W., Najjari, L., Pecks, U., Maass, N. and Rath, W. (2015) Off-Label Use of Misoprostol for Labor Induction in Germany: A National Survey. European Journal of Obstetrics & Gynecology and Reproductive Biology, 187, 85-89.
https://doi.org/10.1016/j.ejogrb.2014.11.026

has been cited by the following article:

• TITLE: Oral Misoprostol 2 Hourly for Labor Induction

  AUTHORS: Souzan Kafy

  KEYWORDS: Recommended Oral Misoprostol Regimen, Induction of Labor

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.8 No.6, June 6, 2018

  ABSTRACT: The objective of this study was to assess the efficacy and safety of the 2 hourly oral misoprostol for labor induction. Between May and November 2013, the hospital records of 83 women who were induced for labor and met the eligibility criteria were retrospectively reviewed. Eligibility criteria were singleton pregnancy of at least 34 weeks’ gestation and a baseline Bishop score 6. Women with a previous cesarean section or other uterine surgery, severe pregnancy-induced hypertension, and parity of 4 or more were excluded. Oral misoprostol was administered as 20 μg 2 hourly unless active labor. A maximum of 12 doses was allowed. The age of the women was 27.9 ± 5.3 years (mean ± SD). Vaginal delivery within 24 hours occurred in 38 (45.8%) women. Cesarean delivery occurred in 17 (20.5%) women. Although more parous women achieved vaginal delivery within 24 hours (52.6%) compared with nulliparous women (40.0%), the difference was not significant (P = .35). Uterine tachysystole occurred in 12 (14.5%) women. No perinatal deaths or neonatal intensive care unit admission occurred in the study group. Evidence supporting an optimal regimen is lacking, and additional research is warranted to optimize the use of oral misoprostol for the induction of labor.