TITLE:
Chromosomal Abnormalities in 238 Couples with Recurrent Miscarriages in Morocco
AUTHORS:
Hanane Houmaid, Chadli El Bekkay, Sanaa Nassereddine, Hayat Talbi, Loubna Amehdare, Abderraouf Hilali
KEYWORDS:
Cytogenetics, Recurrent Abortions, Chromosomal Aberrations
JOURNAL NAME:
Open Journal of Genetics,
Vol.8 No.2,
June
5,
2018
ABSTRACT: Purpose: A proportion of cases
with repeated abortion are caused by chromosomal abnormality in one of the
parents. The purpose of this study was to assess the frequency and nature of
chromosomal aberrations that contribute to the occurrence of recurrent
miscarriages. Several studies have been done to determine the role of chromosomal
abnormalities in couples with recurrent spontaneous abortion in various
countries. None of these studies was done in Morocco. Material and Methods: Cytogenetic study was done for 238 Moroccan couples who presented with repeated
abortion at the Institut Pasteur, Casablanca,
Morocco. Results: We found that the frequency of chromosomal
abnormalities was not significantly different from that reported worldwide.
Chromosomal abnormalities were detected in 13 (6.1%) of 238 couples. twelve of
chromosomal abnormalities were structural and one of them were numerical. Conclusion: This study highlights the importance of constitutional cytogenetic
exploration of couples with a history of repeated spontaneous abortion.
Cytogenetic findings could provide valuable information for genetic counseling
and allow monitoring of future pregnancies by prenatal diagnosis in couples
with a history of recurrent miscarriage.