TITLE:
Prognostic Factors and Treatment Outcome in 178 Locally Advanced Cervical Cancer Patients
AUTHORS:
Ozlem Yetmen Dogan, Makbule Dogan Eren, Sedef Ozdemir Dag, Alparsalan Mayadağli
KEYWORDS:
Locally Advanced Cervix Cancer, Chemo-Radiotherapy, Cervix Cancer
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.8 No.5,
May
14,
2018
ABSTRACT: Background: To evaluate local control, survival, radiation side
effects and treatment outcome in locally advanced cervical cancer patients. Materials and Methods: Among 2006-2011, 178 patients with locally advanced cervical cancer were
treated with chemoradiotherapy +/-radiotherapy and high dose rate (HDR) brachytherapy. Follow-up was
complete for all patients. Concomitant chemotherapy was not administered in 44
patients due to renal impairments and ECOG of 2 - 3. Results: The median follow-up period was 34.5 months (range, 5 to
93) and 42 months (range, 14 to 93 months) for alive patients. Five years
local-regional control, progression-free survival and overall survival rates
were 87.8%, 58.9% and 67.3% in all patients, respectively. In this retrospective
study young age, tumor diameter, stage, presence of residual tumor and
administration of chemotherapy were effected in survival analysis. The
parameters which affected the complete response of patients were defined as
presence of concomitant chemotherapy and number of courses p =
0.044). Conclusion: Primary chemoradiotherapy +/-radiotherapy achieved a satisfactory rate of
local control and survival rates with acceptable complications in locally
advanced cervical cancer. Concomitant chemotherapy and treatment duration were
the important prognostic factors for completed response locally advanced
cervical cancers.