TITLE:
Comparative Efficacy of Frontline Tri-Act® Spot on (Fipronil/Permethrin) versus Seresto® Collar (Imidacloprid/Flumethrin) against Fleas (Ctenocephalides felis) and Ticks (Rhipicephalus sanguineus) on Dogs with Simulation of Bi-Monthly Rain Exposure
AUTHORS:
Frédéric Beugnet, Marielle Servonnet, Lénaïg Halos, Wilfried Lebon
KEYWORDS:
Efficacy, Dogs, Seresto®, Frontline Tri-Act®, Ctenocephalides felis, Rhipicephalus sanguineus
JOURNAL NAME:
Open Journal of Veterinary Medicine,
Vol.8 No.5,
May
30,
2018
ABSTRACT: The objective of the study was to compare the efficacy of one topical insecticide-acaricide (Frontline Tri-Act®) and of one collar (Seresto®) against fleas (Ctenocephalides felis) and ticks (Rhipicephalus sanguineus) on dogs exposed to bi-weekly water showering. Twenty four (24) dogs were enrolled in the study. A first set of 16 dogs were acclimatised to their cages from Day 1 to 7 and a second set of 8 dogs from Day 163 to Day 169. The 24 dogs were randomly allocated to three groups (1 to 3). Dogs assigned to Group 1 were not treated and served as negative controls. Dogs assigned to Group 2 received the Seresto® collar on Day 0 and dogs in Group 3 received Frontline Tri-Act® on Days 170 and 198. The dogs were observed hourly for four hours after treatment administration for possible adverse reactions. Dogs in Groups 1 and 2 underwent water showering on Days 14, 28, 42, 56, 70, 84, 98, 112, 126, 143 and 157. Dogs in all groups underwent water showering on Days 173, 185, 199 and 213. Dogs were infested with approximately 100 (±4) adult, unfed C. felis fleas only on Days 177, 190, 203, and 217, in alternance with infestations with 50 adult unfed R. sanguineus on Days 182, 196, 210, and 224, to assess sustained efficacy. Fleas and ticks were removed and counted on 24 and 48 hours ± 2 hours after each infestation, respectively. Frontline Tri-Act® was >99% effective against C. felis following an initial and a second monthly administration on dogs that were water showered bi-weekly. The Seresto® collar was from 68.3% to 92.9% effective against C. felis Days 178 to 218 after collar administration. Frontline Tri-Act® was effective from 87.8% to 100% against ticks whereas Seresto collar was effective from 82.2% to 94.2% from Day 184 to Day 226.