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Verma, M., Martin, H.-J., Haq, W., O’Connor, T.R., Maser, E. and Balendiran, G.K. (2008) Inhibiting Wild-Type and C299S Mutant AKR1B10; A Homologue of Aldose Reductase Upregulated in Cancers. European Journal of Pharmacology, 584, 213-221.
https://doi.org/10.1016/j.ejphar.2008.01.036

has been cited by the following article:

• TITLE: Synthesis and Chiral Separation of Fibratol, Isopropyl 2-(4-((4-chlorophenyl)(hydroxyl) methyl)-phenoxy)-2-methylpropanoate

  AUTHORS: Amanda E. Kotheimer, Wahajul Haq, Ganesaratnam K. Balendiran

  KEYWORDS: Reduction, Chirality, Optical Activity, Fibrate

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.8 No.2, May 30, 2018

  ABSTRACT: Practical synthetic route for the formation of enantiomeric mixture of Isopropyl 2-(4-((4-chlorophenyl)(hydroxyl)methyl)phenoxy)-2-methylpropanoate (Fibratol 2a/b) from isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate (Fenofibrate 1) has been developed. Method has also been established for the chiral separation of enantiomers of Fibratol 2a/b that is synthesized using the route mentioned above. The optical activity determined for enantiomerically separated Fibratol (2a) and Fibratol (2b) are -5.2° and 8.0° which reflect their ability to rotate plane polarized light counterclockwise (levo) and clockwise (dextro), respectively.