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Zhi, X., Wu, K., Yu, D., Wang, Y., Yu, Y., Yan, P. and Lv, G. (2016) MicroRNA-494 Inhibits Proliferation and Metastasis of Osteosarcoma through Repressing Insulinreceptor Substrate-1. American Journal of Translational Research, 15, 3439-3447.

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• TITLE: Targeting miRNAs in Osteoblast Differentiation under Malnutrition Conditions

  AUTHORS: Yuying Wang, Rui He, Liangjun Zhong

  KEYWORDS: RNA-Seq, microRNA, Osteoblast, Bone Homeostasis

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.6 No.5, May 24, 2018

  ABSTRACT: Aims: Previous studies reported that reduced bone formation was identified in fasting adult female mice compared with the ad libitum control group. An increasing number of studies have shown that miRNAs contribute to bone homeostasis. Unfortunately, there are minor concerns about the underlying mechanisms in osteoblastic differentiation under malnutrition conditions. Methods: We investigated microRNAs (miRNAs) in osteoblastic differentiation under malnutrition conditions using high-throughput bioinformatics approaches. To screen for targeted microRNAs, sequences were quantified by aligning reads to miRbase using miRDeep2 software. Unadjusted p-values were calculated using the Student’s t-test. Genes with a p-value of