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Pickavance, L.C., Tadayyon, M., Widdowson, P.S., Buck- ingham, R.E. and Wilding, J.P.H. (1999) Therapeutic index for rosiglitazone in dietary obese rats. Separation of efficacy and haemodiluation. British Journal of Pharmacology, 128, 1570-1576. doi:10.1038/sj.bjp.0702932

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• TITLE: Preventive effect of Catharanthus roseus (Linn.) against high-fructose diet-induced insulin resistance and oxida-tive stress in male Wistar rats

  AUTHORS: Karuna Rasineni, Saralakumari Desireddy

  KEYWORDS: Catharanthus Roseus; Insulin Resistance; Fructose Diet; HOMA; Oxidative Stress

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.1 No.3, August 31, 2011

  ABSTRACT: High intake of dietary fructose has been shown to exert a number of adverse metabolic effects in humans and experimental animals. The aim of the present study was to investigate whether Catharanthus roseus (L.) G. Don (Apocynaceae) leaf powder alleviates high-fructose diet-induced insulin resistance and oxidative stress in rats. Adult male Wistar rats of body weight around 200 g were divided into four groups, two of which were fed with standard pellet diet and the other two with high fructose (66%) diet. C. roseus leaf powder suspension in water (100 mg/kg body weight/day) was administered orally to each group of the standard pellet diet fed rats and the high fructose diet fed rats for 60 days. Fructose fed rats (F-group) showed hyperglycemia, hyperinsulinemia, insulin resistance and hyperlipidemia (P