TITLE:
Various Routes to Synthesise 3-Thioxo-1,2,4-Triazine-5-One Derivatives as Antimicrobial Agents
AUTHORS:
Reda M. Abdel-Rahman, Wafa A. Bawazir
KEYWORDS:
Synthesis, Antimicrobial, 3-Thioxo-1, 2, 4-Triazin-5-Ones
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.8 No.2,
May
7,
2018
ABSTRACT: A simple condensation
afforded some new
3-thioxo-1,2,4-triazin-5-one derivatives (4, 6 and 8).
Utilizing a facile condensation of (E)-4-(4’-bromo styryl)-2-oxo-3-buteneoic acid with thiosemicarbazide, dithioic formic acid hydrazide,
and thiocarbahydrazide in different conditions. Structures of these compounds
were confirmed by elemental and spectral analysis. The preliminary biocidal
activity of these products were evaluated against some microbial and compared
to Mycostatine and piperacillin as antibiotics were most of derivatives
exhibited good activity.