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Shibata, T., Kanayama, M., Haida, M., Fujimoto, S., Oroguchi, T., Sata, K., Mita, N., Kutsuzawa, T., Ikeuchi, M., Kondo, M., Naito, K., Tsuda, M., Nishizaki, Y. and Ishii, N. (2016) Lactococcus lactis JCM5805 Activates Anti-Viral Immunity and Reduces Symptoms of Common Cold and Influenza in Healthy Adults in a Randomized Controlled Trial. Journal of Functional Foods, 24, 492-500.
https://doi.org/10.1016/j.jff.2016.03.035

has been cited by the following article:

• TITLE: Safety Evaluation of Excessive Intake of Lactococcus lactis Subsp. lactis JCM 5805: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial

  AUTHORS: Yukiko Kato, Masaya Kanayama, Shu Yanai, Hajime Nozawa, Osamu Kanauchi, Satoru Suzuki

  KEYWORDS: Lactic Acid Bacteria, Lactococcus lactis, Excessive Intake, Safety

  JOURNAL NAME: Food and Nutrition Sciences, Vol.9 No.4, April 30, 2018

  ABSTRACT: Background/Aims: Administration of a lactic acid bacterial strain, Lactococcus lactis subsp. lactis JCM 5805 (LC-Plasma), is reported to prevent viral infection via activation of plasmacytoid dendritic cells in mouse and human studies. As it is assumed that LC-Plasma is taken in excess when it is commercially provided as a supplement, we conducted a trial using capsules to give 250 mg LC-Plasma (5 times the effective anti-viral dose) every day for four weeks to healthy volunteers to investigate the safety of excessive intake of LC-Plasma. Trial Design: A randomized, double-blind, placebo-controlled, parallel-group trial was conducted. Methods: Forty healthy subjects were randomly assigned to the LC-Plasma group (daily intake of five capsules containing 50 mg heat-killed LC-Plasma cells per capsule) or the placebo group (daily intake of five placebo capsules with no LC-Plasma). Physical, hematological, biochemical and urinary examinations and medical interviews were used to evaluate safety. Results: No abnormal differences were observed after excessive intake of LC-Plasma capsules when compared to the intake of placebo capsules. Conclusions: There are no safety concerns associated with the excessive intake of heat-killed LC-Plasma capsules.