TITLE:
Profile of Patients with Breast Cancer Brain Metastasis in Abidjan
AUTHORS:
Kouame Konan Yvon Kouassi, Moctar Touré, Evrard Narcisse Seka, Oumou Kimso, Mudasiru Akanji Oseni, Bitti Adde Odo, Arsène Gaetan Kagambega, Innocent Adoubi
KEYWORDS:
Breast Cancer, Brain Metastasis, Abidjan
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.7 No.2,
April
30,
2018
ABSTRACT: Patients with breast cancer will develop brain metastases in 15% - 25% of
cases. Objective: To identify the profile of patients with breast cancer
brain metastasis. Method: Retrospective study over 4 years in the
oncology department of Treichville Hospital. All patients with breast carcinoma
who had a brain metastasis during their cancer management were
included. Results: 41 cases of breast carcinoma brain metastasis were
collected. Patients were older than 40 years in 78% of cases. Family history of
breast cancer was found in 7% of patients. More than 80% of patients had
consulted with T3 and T4 tumor masses, with 100% of cases of node involvement.
The brain was the second site of metastasis. The tumors were Triple negative in
48%, Her2 positive in 36% and luminal in 16%. Brain metastases were of late
onset in the majority of cases (68%). They were clinically characterized by
headaches (100%), most often included in an intracranial hypertension syndrome
(52%). They were multiple (60%). Therapeutically, no surgery was performed on
the metastases. Three patients received whole brain radiation therapy. All
patients received systemic therapy. In terms of response, 30 cases of
progression were observed after treatment and 2 cases of complete response were
obtained. Survival from onset of brain metastasis was of 75% at 3 months and 2%
at 12 months. Patients with longer survival rates were over 40 years old with
triple negative breast cancer. Conclusion: Brain metastasis from breast
cancer most often occurs in a particular clinical and pathological context in
our countries.