TITLE:
A Novel Dihydropyridines C-Glycosylated Compound by Hantzsch Cyclo-Condensation
AUTHORS:
Soheila Sedaghat, Shabnam Madjdpour
KEYWORDS:
1, 4-Dihydropyridines, c-Glycosylated, Multi Component Reaction, Hantzsch Reaction
JOURNAL NAME:
Open Journal of Synthesis Theory and Applications,
Vol.7 No.2,
April
28,
2018
ABSTRACT: The Hantzsch synthesis has been used for the preparation of the 1,4-Dihydropyridines compounds with different pharmacophore groups. The use of a designed glycosylated compound in Hantzsch synthesis would lead to a novel Dihydropyridines C-Glycosylated compound. We used the 6-methoxy-2, 2-dimethyltetrahydrofuro [3, 4-d] [1, 3] dioxole-4-carbaldehyde as a glycosylated-based aldehydes. The 4-(3,4-Dihydroxy-5-methoxy-tetrahydro-furan-2-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxy-lic acid 3-ethyl ester 5-methyl ester was synthesized. The structure of compounds was determined by NMR spectroscopy, FTIR and mass spectroscopy methods. We synthesized this 1,4-Dihydropyridines compound by ionic liquid under ultrasound irradiation as a green chemistry synthesis.