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E. Charafe-Jauffret, K. Mrad, S. Labidi, A. Ben Hamida, K. Ben Romdhane, M. Ben Abdallah, C. Ginestier, B. Esterni, D. Birnbaum, F. Ben Ayed, L. Xerri, A. Mezlini and J. Jacquemier, “Inflammatory Breast Cancers in Tunisia and France Show Similar Immunophenotypes,” Breast, Vol. 16, No. 4, 2007, pp. 352-358. doi:10.1016/j.breast.2007.01.002

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• TITLE: The Effect of Overweight on The Risk of Recurrence in Tunisian Patients with Operable Breast Cancer

  AUTHORS: Inès Ayadi Masmoudi, Amine Masmoudi, Nabil Toumi, Afef Khanfir, Mounir Frikha, Jamel Daoud

  KEYWORDS: Adjuvant Chemotherapy, Early Breast Cancer, Obesity, Recurrence, Tunisia

  JOURNAL NAME: Journal of Cancer Therapy, Vol.2 No.3, August 24, 2011

  ABSTRACT: Obesity is associated with worse breast cancer outcomes in Western and Asian women. The present study was to determine the relation of body mass index (BMI) to disease-free survival (DFS) in Tunisian patients with operable breast cancer. We retrospectively reviewed data from 223 patients with operable breast cancer treated with primary surgery and adjuvant epirubicin-based chemotherapy. Patients were categorized into lower-BMI (2; N=114) v higher-BMI (>27.5 kg/m2; N=113). Patients’and disease characteristics, including tumor size and lymph node status, were similar between the 2 groups. With a median follow-up of 56 months, there were 42 and 30 DFS events in the lower- and higher-BMI group, respectively (adjusted hazard ratio (HR): 0.74; 95% CI, 0.43 to 1.26; p=0.26). A significant interaction (p