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P. Singh, T. E. Peterson, A. Romero-Corral, D. E. Davidson, M. D. Jensen and V. K. Somers, “Identification of Caveolin-1 as an Inhibitor of Leptin Signaling: Implications for Leptin Resistance in a Human Weight Gain Model,” Circulation, Vol. 118, 2008, p. S278.

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• TITLE: The Effect of Overweight on The Risk of Recurrence in Tunisian Patients with Operable Breast Cancer

  AUTHORS: Inès Ayadi Masmoudi, Amine Masmoudi, Nabil Toumi, Afef Khanfir, Mounir Frikha, Jamel Daoud

  KEYWORDS: Adjuvant Chemotherapy, Early Breast Cancer, Obesity, Recurrence, Tunisia

  JOURNAL NAME: Journal of Cancer Therapy, Vol.2 No.3, August 24, 2011

  ABSTRACT: Obesity is associated with worse breast cancer outcomes in Western and Asian women. The present study was to determine the relation of body mass index (BMI) to disease-free survival (DFS) in Tunisian patients with operable breast cancer. We retrospectively reviewed data from 223 patients with operable breast cancer treated with primary surgery and adjuvant epirubicin-based chemotherapy. Patients were categorized into lower-BMI (2; N=114) v higher-BMI (>27.5 kg/m2; N=113). Patients’and disease characteristics, including tumor size and lymph node status, were similar between the 2 groups. With a median follow-up of 56 months, there were 42 and 30 DFS events in the lower- and higher-BMI group, respectively (adjusted hazard ratio (HR): 0.74; 95% CI, 0.43 to 1.26; p=0.26). A significant interaction (p