TITLE:
The Effect of Overweight on The Risk of Recurrence in Tunisian Patients with Operable Breast Cancer
AUTHORS:
Inès Ayadi Masmoudi, Amine Masmoudi, Nabil Toumi, Afef Khanfir, Mounir Frikha, Jamel Daoud
KEYWORDS:
Adjuvant Chemotherapy, Early Breast Cancer, Obesity, Recurrence, Tunisia
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.2 No.3,
August
24,
2011
ABSTRACT: Obesity is associated with worse breast cancer outcomes in Western and Asian women. The present study was to determine the relation of body mass index (BMI) to disease-free survival (DFS) in Tunisian patients with operable breast cancer. We retrospectively reviewed data from 223 patients with operable breast cancer treated with primary surgery and adjuvant epirubicin-based chemotherapy. Patients were categorized into lower-BMI (2; N=114) v higher-BMI (>27.5 kg/m2; N=113). Patients’and disease characteristics, including tumor size and lymph node status, were similar between the 2 groups. With a median follow-up of 56 months, there were 42 and 30 DFS events in the lower- and higher-BMI group, respectively (adjusted hazard ratio (HR): 0.74; 95% CI, 0.43 to 1.26; p=0.26). A significant interaction (p