TITLE:
Evaluation of Antimycotic Activity of Extracts of Marine Algae Collected from Red Sea Coast, Jeddah, Saudi Arabia
AUTHORS:
Huda Sheikh, Amal El-Naggar, Danyah Al-Sobahi
KEYWORDS:
Marine Algae, Seaweeds, Antifungal Activity, Solvent Extracts, Minimal Inhibitory Concentrations (MICs)
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.6 No.4,
April
24,
2018
ABSTRACT: In the
present study, fifteen species of the dominant marine algae were collected
during summer 2013 from four selected sites on Red sea coast, Jeddah,
Saudi Arabia. The collected species belonged to Chlorophyta, Phaeophyta and Rhodophyta. Crude algal extracts were prepared by
successive extractions using different solvents (acetone, ethanol, diethyl
ether, ethyl acetate, methanol and petroleum ether). The crude algal extracts
were examined for their antifungal efficacy against Aspergillus flavus, Aspergillus fumigatus, Aspergillus
niger, Candida albicans and Candida tropicalis using agar well
diffusion method. The algal extracts evoked different patterns of antifungal
activities. Results reveal that acetone was the best solvent suited for
extraction of bioactive compounds from tested seaweeds with inhibition activity
(19.3%) followed by ethyl acetate (17.1%), ethanol (16.4%), petroleum ether
(15.9%), diethyl ether (15.85%), and finally methanol (15.4%). Chlorophyta
exhibited the highest antimycotic effect followed by Rhodophyta and Phaeophyta.
In Chlorophyta, the extracts of Ulva
intestinalis were the most potent followed by U. lactuca, C. racemosa, U. linza and U. reticulate. Acanthophora
spicifera showed the highest activity in Rhodophyta, followed by J.
rubens, D. simplex, L. obtusa, G. gracilis, G. vermicuphylla and G. multipartita. Whereas, T. triquetra was the most effective
species in Phaeophyta followed by P.
pavonica and D. dichotoma. The
minimal inhibitory concentrations (MICs) of the most potent algal extracts were
in the range of 0.5 to 4 mg/ml. The results confirmed the antimycotic
potentiality of seaweed extracts.