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Sonnenburg, E.D., Zheng, H., Joglekar, P., Higginbottom, S.K., Firbank, S.J., Bolam, D.N., Sonnenburg, J.L. (2010) Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterations. Cell, 141, 1241-1252.

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• TITLE: Dietary sugars inhibit biologic functions of the pattern recognition molecule, mannose-binding lectin

  AUTHORS: Kazue Takahashi, Wei-Chuan Chang, Patience Moyo, Mitchell R. White, Parool Meelu, Anamika Verma, Gregory L. Stahl, Kevan L. Hartshorn, Vijay Yajnik

  KEYWORDS: Mannose-Binding Lectin; Fructose; Influenza A Virus; Staphylococcus Aureus; Complement; Coagulation

  JOURNAL NAME: Open Journal of Immunology, Vol.1 No.2, September 30, 2011

  ABSTRACT: Mannose-binding lectin (MBL), a mammalian lectin, is a pattern recognition molecule of the innate immune system and recognizes carbo-hydrates that are exposed on pathogens. In this study, we observed that fructose down regu-lates MBL-mediated innate immune mechanisms against both influenza A virus (IAV) and Staphy-lococcus aureus. These mechanisms include the lectin complement pathway and coagulation enzyme-like activities on both pathogens. Fur-thermore, fructose also reduces MBL-mediated phagocytosis of S. aureus and IAV and MBL- mediated IAV infection to epithelial cells. In contrast, sucrose inhibits MBL-mediated im-mune mechanisms against S. aureus but not IAV. Together, our studies show that dietary sugars, in particular fructose, negatively regulate the innate immunity against viral and bacterial pathogens.