TITLE:
SPARC Expression as a Prognostic Marker in Pancreatic Ductal Adenocarcinoma
AUTHORS:
Jianxing Zhang, Peiyu Ji, Xin Fan, Xiaoyan Ma, Xuqing Wang, Zhengfa Mao
KEYWORDS:
Pancreatic Adenocarcinoma, SPARC, Prognosis, Surgery
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.8 No.4,
April
11,
2018
ABSTRACT: Background: The aim is to investigate whether secreted protein acidic and rich in cysteine (SPARC) expression could be considered as an independent prognostic factor in pancreatic ductal adenocarcinoma (PDAC). Methods: The expression of SPARC in the tumor species was detected by immunochemistry and the effect of SPARC on the prognosis was analyzed by Kaplan-Meier and Cox proportional hazard models. Results: Positive SPARC expressions recognized in tumor and stroma were 31.33% and 64.66% respectively. The expression of SPARC in stroma was closely correlated with differentiation, vascular invasion and was an indicator for predicting poor outcome after surgery in Kaplan-Meier analysis. Univariate analysis and multivariate analysis showed the following factors to be significant: perineural invasion (HR = 2.098, 95% CI: 1.144 - 3.847) and stroma positive expression of SPARC (HR = 2.120, 95% CI: 1.307 - 3.440). Conclusions: High expression of SPARC in stroma was a promising pathological marker to predict the poor outcome in patients with pancreatic ductal adenocarcinoma.