TITLE:
Role of Electrical Forces in Angiogenesis
AUTHORS:
Oliver Szasz, Gyula Peter Szigeti, Andras Szasz, Zoltan Benyo
KEYWORDS:
Angiogenesis, Polarization, Electric Field, Injury Current, Wound Healing, Malignant Proliferation, Endothelial Cells, Epithelial Cells, Mesenchymal Cells, Cell Transitions
JOURNAL NAME:
Open Journal of Biophysics,
Vol.8 No.2,
April
2,
2018
ABSTRACT: The role of electrical forces in angiogenesis is widely studied. The electric field (EF) induces polarization of the endothelial cells, and in this way, it is a morphogen in angiogenesis. Additional to the polarization, it may build up by newborn cells in the process of cellular fission. Due to the weak direct experimental results on the transitions of endothelial cells, we used an analogy to these epithelial transitions. This involved using the injury current, which induces oriented cell migration and morphological arrangement in wound healing. The injury-current considerations are applied for malignant proliferation as well.