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Friedenberger, M., Bode, M., Krusche, A. and Schubert, W. (2007) Fluorescence Detection of Protein Clusters in Individual Cells and Tissue Sections by Using Toponome Imaging System (TIS): Sample Preparation and Measuring Procedures. Nature Protocols, 2, 2285-2294.
https://doi.org/10.1038/nprot.2007.320

has been cited by the following article:

• TITLE: A Platform for Parameter Unlimited Molecular Geometry Imaging Obviously Enabling Life Saving Measures in ALS

  AUTHORS: Walter Schubert

  KEYWORDS: Geometry, Toponome, ALS, Motor Neuron Disease, Imaging, Toponome-Therapy

  JOURNAL NAME: Advances in Pure Mathematics, Vol.8 No.3, March 27, 2018

  ABSTRACT: This article deals with a molecular geometry imaging platform capable of mapping the spatial protein-colocalisation and anti-colocalisation code of large molecular systems at a time. The platform called molecular unlimited systems imaging cycler (MUSIC) robotics was applied to amyotrophic lateral sclerosis (ALS). The detection of ALS specific cells with a corresponding multimolecular geometry in the blood led to therapeutic depletion of these cells and to recovery of the treated patient, obviously because this therapy interferes with pathogenic invasion of these cells into the central nervous system, where they axotomize motor axons. Large scale geometry MUSIC robotics imaging of up to 4.5 × 10481 power of combinatorial molecular resolution is key to detect these cells and to control depletion therapy for clinical success. These data and new possibilities may argue for clinical application and for a systematic research in the field of molecular geometry of diseases to discover new mathematically defined insight.