TITLE:
Successful Combination Therapy of Nivolumab and Radiation for Massive Mucosal Melanoma in Patient with Autoimmune-Myasthenia Gravis, Systemic Lupus Erythematosus and Rheumatoid Arthritis
AUTHORS:
Asako Ota, Atsushi Tanemura, Reika Aoyama, Yorihisa Kotobuki, Keita Kakuta, Kohei Tsujimoto, Toshiro Tanaka, Shigeaki Suzuki, Ichiro Katayama
KEYWORDS:
Anti PD-1 Antibody, Radiation, Malignant Melanoma, Myasthenia Gravis
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.8 No.1,
March
23,
2018
ABSTRACT: A 58-year-old woman complicated with autoimmune diseases of myasthenia
gravis (MG), rheumatoid arthritis, and systemic lupus erythematosus noticed an
irregular black macule on her bilateral major labia, which was diagnosed as malignant melanoma. The melanoma lesion involving the
vagina, uterus, and ventral side of rectum was not operable and was treated
with nivolumab and concurrent radiotherapy with good control of the MG. This
resulted in remarkable tumor shrinkage, possibly due to synergistic effects of both
treatments. To our knowledge, few reports have described the effectiveness of
combination therapy with nivolumab and radiation for malignant melanoma. The
present case showed an enhanced anti-tumor effect with combination therapy.