TITLE:
Prognostic Significance of Hematologic Markers in Patients with Head and Neck Squamous Cell Carcinomas
AUTHORS:
Ryohei Oya, Yukinori Takenaka, Kengo Aoki, Hiroko Hamaguchi, Kazuya Takemura, Masayuki Nozawa, Takahiro Kitamura, Yoshifumi Yamamoto, Atsuhiko Uno
KEYWORDS:
Biomarkers, Head and Neck Cancer, Hematologic Marker
JOURNAL NAME:
International Journal of Otolaryngology and Head & Neck Surgery,
Vol.7 No.2,
March
22,
2018
ABSTRACT: Aim: To assess the prognostic value of hematologic markers for cancers of the head and neck region, according to tumor site. Methods: We reviewed the data of 441 patients diagnosed with head and neck squamous cell carcinomas (HNSCC) between 2006 and 2014. Overall survival rates were estimated using the Kaplan-Meier method and Cox proportional hazards models were used to assess the hazard ratio (HR) for death, according to hematologic markers. Results: In the univariate analyses, hemoglobin concentration; leukocyte, neutrophil, monocyte, and platelet counts; and the platelet-lymphocyte ratio were associated with overall survival. In the multivariate analyses, hemoglobin concentration (HR 0.55, 95% confidence interval [CI] 0.38 - 0.78, p Conclusions: Several hematologic markers have prognostic significance for patients with HNSCC, however, the magnitude of the effect depends on the tumor site.