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Xia, T., Chen, S., Jiang, Z., Shao, Y., Jiang, X., Li, P., et al. (2015) Long Noncoding RNA FER1L4 Suppresses Cancer Cell Growth by Acting as a Competing Endogenous RNA and Regulating PTEN Expression. Scientific Reports, 5, Article No. 13445.

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• TITLE: Role of lncRNAs in GI Cancer

  AUTHORS: Murali Krishna, Anju Mullath

  KEYWORDS: lncRNA, Cancer, Pancreatic, Gastric, Hepatocellular, Colorectal

  JOURNAL NAME: Journal of Cancer Therapy, Vol.9 No.3, March 19, 2018

  ABSTRACT: lncRNAs forms a part of the non coding part of human genome. This term denotes specific non coding RNAs with nucleotide length more than 200. They have been shown to affect various physiological and pathological processes within the human body. Of interest is their role in malignant transformation in several cancers. In this review, the role of lncRNAs in GI cancers namely pancreatic cancer, gastric cancer, hepatocellular cancer and colorectal cancer have been explained in brief. These lncRNAs have shown to be useful as a marker for detection and prognosis of various malignancies. They also have shown to have therapeutic potential. Various relevant lncRNAs in each section has also been mentioned.