TITLE:
Role of lncRNAs in GI Cancer
AUTHORS:
Murali Krishna, Anju Mullath
KEYWORDS:
lncRNA, Cancer, Pancreatic, Gastric, Hepatocellular, Colorectal
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.9 No.3,
March
19,
2018
ABSTRACT: lncRNAs forms a part of the non coding part of human
genome. This term denotes specific non coding RNAs with nucleotide length more
than 200. They have been shown to affect various physiological and pathological
processes within the human body. Of interest is their role in malignant transformation
in several cancers. In this review, the role of lncRNAs in GI cancers namely pancreatic cancer, gastric
cancer, hepatocellular cancer and colorectal cancer have been explained in brief. These lncRNAs have shown to be useful as a
marker for detection and prognosis of various malignancies. They also have
shown to have therapeutic potential. Various relevant lncRNAs in each section
has also been mentioned.