TITLE:
A Novel Combined Approach for Metastatic Breast Cancer with Dural and Leptomeningeal Disease with an Impressive Clinical Outcome: A Case Study
AUTHORS:
Julie Taguchi, Christopher Duma, M. A. Nezami
KEYWORDS:
Breast Cancer, Metastatic, Leptomeningeal Disease, Dural Disease
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.9 No.3,
March
19,
2018
ABSTRACT: Concurrent dural and leptomeningeal metastatic carcinomatosis
are very rare and have a poor prognosis. Here we present a woman with advanced
estrogen receptor (ER) positive and progesterone receptor (PR) positive breast
cancer who presented with leptomeningeal disease. Patient underwent multi
targeted epigenetic therapies applied in a protocol called MTET. She continued
to respond to the interval treatment, which consisted only of the nutraceutical
agents. Here we discuss her case in detail and we believe that such an example
might be applied to other patients in this situation resulting clinical improvement
and less toxicity.