TITLE:
The Effect of Aqueous Extract of Cecropia glazioui Snethlage (Embauba) in the Rat Fetal Development
AUTHORS:
Priscila Randazzo-Moura, Magali Glauzer Silva, Yoko Oshima-Franco, Francisco Carlos Groppo, Marli Gerenutti
KEYWORDS:
Fetuses’ Abnormalities, Medicinal Plants, Teratogenesis
JOURNAL NAME:
Chinese Medicine,
Vol.2 No.3,
September
30,
2011
ABSTRACT: The effect of aqueous extract of Cecropia glazioui Snethlage (Embauba) in the rat fetal development. This study was to complement previous assays on the physical and neurobehavioral development of rats resulted from oral administration of 1 g/kg/day Cecropia glazioui Snethlage (C. glazioui) aqueous extract (LD50 > 5 g·kg-1in pregnant rats (peri- and post-natal studies). In the present study, the effect of 2.5 g/kg/week C. glazioui aqueous extract, administered to pregnant rats during 15 days, was verified in the rat offspring development. No acute or chronic toxicity (no effects on mortality or weight average daily gain) were observed. In addition, no effects on reproductive parameters (offspring vitality, placenta and fetus weight, number of corpora lutea on each ovary, pre- and post-implantation loss) and on offspring external morphology were found. We concluded that C. glazioui aqueous extract administered during pregnancy did not cause abnormalities in rat offspring.