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Place, A.E., Suh, N., Williams, C.R., Risingsong, R., Honda, T., Honda, Y., et al. (2003) The Novel Synthetic Triterpenoid, CDDO-Imidazolide, Inhibits Inflammatory Response and Tumor Growth in vivo. Clinical Cancer Research, 9, 2798-2806.

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• TITLE: Metals Complexes Formed with Oleanolic Acid

  AUTHORS: Nilton C. Ribeiro, Antonio J. Demuner, Marcelo H. dos Santos, Célia R. A. Maltha, Elson A. de Alvarenga, Slavko Komarnytsky

  KEYWORDS: Oleanolic Acid, Complex, PCR

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.8 No.1, March 12, 2018

  ABSTRACT: The oleanolic acid possesses diverse pharmacological properties, it is considered as a good starting material for creating new compounds. The oleanolic acid isolated of Plumeria obtusa leaves was used as raw material to obtained calcium, magnesium, zinc, nickel and copper complexes. The structures of complexes were confirmed by HRMS, 1H NMR, and 13C NMR. Five new compounds were synthesized to promote increased biological activity of oleanolic acid and PCR assays for the different type of cancer.