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Polyzos, A., O’Brien, M., Peterson, T.P., Baxendale, I.R. and Ley, S.V. (2011) The Continuous-Flow Synthesis of Carboxylic Acids Using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor. Angewandte Chemie International Edition, 50, 1190-1193.
https://doi.org/10.1002/anie.201006618

has been cited by the following article:

• TITLE: Safe Hydroformylation of Aliphatic Alkene in a Flow Reactor

  AUTHORS: Hisashi Masui, Eiki Honda, Sakura Niitsu, Mitsuru Shoji, Takashi Takahashi

  KEYWORDS: Hydroformylation, Flow Synthesis, Alkene, Carbon Monoxide, Aldehyde

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.8 No.1, March 9, 2018

  ABSTRACT: Despite hydroformylation being a very efficient method for the transformation of alkenes, it is not commonly employed in laboratories owing to the flammable/toxic nature of hydrogen and carbon monoxide gases and the necessity of high-pressure equipment in a batch system. Flow chemistry often raises the safety profiles against high-pressure and toxic gases because the diameter of the flow reactor is small. Herein, we show that aliphatic alkenes can be safely hydroformylated in a flow reactor. In our flow method, although the target hydroformylated product was obtained in a low yield (19%), toxic gases were safely treated using a flow reactor. Better yields could possibly be achieved by recycling of the unreacted alkene.