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Airiau, E., Spangenberg, T., Girard, N., Breit, B. and Mann, A. (2010) Short Access to (+)-Lupinine and (+)-Epiquinamide via Double Hydroformylation. Organic Letters, 12, 528-531.
https://doi.org/10.1021/ol902718q

has been cited by the following article:

• TITLE: Safe Hydroformylation of Aliphatic Alkene in a Flow Reactor

  AUTHORS: Hisashi Masui, Eiki Honda, Sakura Niitsu, Mitsuru Shoji, Takashi Takahashi

  KEYWORDS: Hydroformylation, Flow Synthesis, Alkene, Carbon Monoxide, Aldehyde

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.8 No.1, March 9, 2018

  ABSTRACT: Despite hydroformylation being a very efficient method for the transformation of alkenes, it is not commonly employed in laboratories owing to the flammable/toxic nature of hydrogen and carbon monoxide gases and the necessity of high-pressure equipment in a batch system. Flow chemistry often raises the safety profiles against high-pressure and toxic gases because the diameter of the flow reactor is small. Herein, we show that aliphatic alkenes can be safely hydroformylated in a flow reactor. In our flow method, although the target hydroformylated product was obtained in a low yield (19%), toxic gases were safely treated using a flow reactor. Better yields could possibly be achieved by recycling of the unreacted alkene.