TITLE:
Synthesis and Spectral Characterization of Novel 2-Pyrazoline and Bis-2-Pyrazoline Containing Quinoline Moiety
AUTHORS:
Allaoua Kedjadja, Abdelmalek Bouraiou, Rachid Merdes
KEYWORDS:
Pyrazoline, Chalcone, Quinoline, Cyclocondensation
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.8 No.1,
March
7,
2018
ABSTRACT: Eight new
compounds containing in their structures substituted quinoline and pyrazole entity
were synthesized in good to excellent yield by cyclocondensation reaction of chalcones
and hydrazine hydrate. This reaction was conducted
in formic acid in presence of BF3·Et2O or in acetic acid.
These approaches were extended to bis-chalcones, which delivered functionalized
bispyrazolines. The structures of the prepared compounds were confirmed by IR, 1HNMR, 13CNMR and mass spectral analysis.