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Onda, T., Kobayashi, H., Nakanishi, T., Hatae, M., Iwasaka, T., Konishi, I., et al. (2009) Feasibility Study of Neoadjuvant Chemotherapy Followed by Interval Debulking Surgery for Stage III/IV Ovarian, Tubal, and Peritoneal Cancers: Japan Clinical Oncology Group Study JCOG0206. Gynecologic Oncology, 113, 57-62.
https://doi.org/10.1016/j.ygyno.2008.12.027

has been cited by the following article:

• TITLE: Feasibility of Upfront Debulking Surgery versus Neoadjuvant Chemotherapy Followed by Interval Debulking Surgery for Advanced Ovarian Cancer

  AUTHORS: Amen Hamdy Zaky, Adel Gabr, Doaa Wadie Maximous, Ahmed A. S. Salem, Amr Farouk Mourad, Haisam Atta, Marwa Ismail

  KEYWORDS: Advanced Ovarian Cancer, Debulking Surgery, Neoadjuvant Chemotherapy

  JOURNAL NAME: Journal of Cancer Therapy, Vol.9 No.2, February 26, 2018

  ABSTRACT: Background: Inappropriately ovarian cancer cannot be detected until an advanced stage. Radical debulking surgery is considered the cornerstone in the management of advanced ovarian cancer pointing to complete tumor resolution. Unless optimal debulking cannot be achieved, these patients gain little benefit from surgery. Neoadjuvant chemotherapy (NACT) has been recommended as a novel therapeutic modality to a diversity of malignant tumors when the disease is not willing to optimal surgical resection at the time of diagnosis or the patient who unfit for aggressive debulking surgery. The purpose of this study is to compare survival in the patient with advanced ovarian cancer (stage III/IV) underwent primary debulking surgery followed by adjuvant chemotherapy (PDS-ACTR) to those who received neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS). Results: Neoadjuvant chemotherapy (NACT-IDS) showed significant complete cytoreduction and decreased in surgical morbidity in comparison to primary debulking surgery (PDS-ACTR). NACT-IDS showed significant improvement in progression-free survival (P-value 0.002) and overall survival (P-value 0.03) in comparison to PDS-ACTR. Response to NACT and residual volume were the two independent prognostic factors for overall survival. Conclusion: NACT-IDS for advanced ovarian cancer (III/IV) resulted in higher frequency of complete resection with no residual tumor, less post-operative surgical morbidity and significant increase progression-free survival and overall survival. Both responses to NACT and residual tumor volume were the two independent prognostic factors for survival in ovarian cancer.