TITLE:
The Efficacy of the Consumption of n-3 Polyunsaturated Fatty Acids for the Maintenance of Remission in Patients with Inflammatory Bowel Disease
AUTHORS:
Kan Uchiyama, Hiroko Aiki, Aki Matsumura, Kanako Saruta, Ai Yuasa, Zensho Ito, Shinichiro Takami, Keisuke Saito, Yuichiro Ohtaki, Shizuka Suzuki, Susumu Hayashi, Shigeo Koido, Hiroshi Yoshida, Toshifumi Ohkusa, Masayuki Saruta
KEYWORDS:
Crohn’s Disease, Inflammatory Bowel Disease, N-3 Diet, Polyunsaturated Fatty Acid, Ulcerative Colitis
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.9 No.2,
February
24,
2018
ABSTRACT: The aim of the present study was to investigate the efficacy of the actual consuming n-3 PUFA for remission-maintenance in IBD patients. A questionnaire on the dietary habits of patients one month before hospitalization (Q1) was completed by 24 patients with IBD (10 ulcerative colitis (UC) subjects and 14 Crohn’s disease (CD) subjects) treated at our hospital. We educated the study subjects about an n-3 PUFA diet, and a follow-up survey (Q2) was conducted 6 to 12 months after discharge. Disease activity was evaluated using the International Organization for the Study of Inflammatory Bowel Disease (IOIBD) score and/or the Crohn’s Disease Activity Index (CDAI) score for CD and the partial UCDAI score without endoscopic evaluation for UC. Q1 showed that the average n-3 and n-6 PUFA intakes were 1673 ± 1651 mg and 9146 ± 5217 mg, respectively, and the average n-3/n-6 ratio was 0.27 ± 0.31. In Q2, the intake of n-3 PUFA was significantly higher (3671 ± 1684 mg, p