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Biehl, L.M., Huth, A., Panse, J., Krämer, C., Hentrich, M., Engelhardt, M., Ko, G., Kiehl, M., Wendtner, C., Karthaus, M., Ullmann, A.J., Hellmich, M., Christ, H. and Vehreschild, M.J.G.T. (2016) A Randomized Trial on Chlorhexidine Dressings for the Prevention of Catheter-Related Bloodstream Infections in Neutropenic Patients. Annals of Oncology, 27, 1916-1922.
https://doi.org/10.1093/annonc/mdw275

has been cited by the following article:

• TITLE: Local Cutaneous Effects Associated with Chlorhexidine-Impregnated Gel Dressing in Hematopoietic Stem Cell Transplantation Patients

  AUTHORS: Bruna Nogueira dos Santos, Maria Carolina de Oliveira, Fernanda T. M. M. Braga, Amanda Salles Margatho, Laís C. C. Esparrachiari, Renata C. de C. P. Silveira

  KEYWORDS: Bandages, Catheterization, Central Venous Catheters, Hematopoietic Stem Cell Transplantation, Skin Abnormalities

  JOURNAL NAME: Open Journal of Nursing, Vol.8 No.2, February 13, 2018

  ABSTRACT: Introduction: Hematopoietic stem cell transplantation (HSCT) often requires a central venous catheter (CVC) for quick and safe vascular access. Currently, new technologies are available to protect the catheter insertion site, such as chlorhexidine-impregnated gel dressings (CIGD). Objectives: To evaluate local cutaneous effects associated with CIGD in patients undergoing HSCT. Methods: In this cross-sectional, prospective study, we evaluated 25 HSCT patients who had a CVC inserted. Patients were visited daily to monitor the CIGD changing procedures and evaluate abnormalities of the underlying skin after dressing removal. Findings: Local erythema was the most frequently detected abnormality, although usually transient and considered secondary to the mechanical trauma of dressing removal. The most severe lesions, consisting of areas of skin loss, erythematous plaques and/or vesicles were classified as skin irritation and presented in 11 (44%) of the 25 patients. An association test showed that skin irritation was more frequent in patients who underwent allogeneic HSCT (p = 0.03). Skin irritation was most frequently observed in areas of contact with the non-woven polyester adhesive tape (n = 22; 88%), which made up the adhesive margins of the dressing. The CIGD was discontinued in 6 (54%) of the 11 patients who presented severe skin injuries. Conclusion: In this study, we detected that skin irritation was more frequent in patients who underwent allogeneic HSCT. The most common skin manifestation was skin loss.