TITLE:
Parkinson Kinetic Graph: Are Motor Fluctuations in Parkinson Disease Related with Disease Duration?
AUTHORS:
Esther Berghuis, Barbera Van Harten, Mirjam Van Kesteren-Biegstraaten, Wijnand Rutgers, Nicolaas Verwey
KEYWORDS:
Late Stage Parkinson Disease, Levodopa, Disease Duration, Fluctuations, Dyskinesia, Bradykinesia
JOURNAL NAME:
Advances in Parkinson's Disease,
Vol.7 No.1,
January
31,
2018
ABSTRACT: Introduction: The Parkinson’s KinetiGraph (PKG) is a digital measurement
system for motor fluctuations (FS). The aim of this study is to investigate
whether FS, measured by the PKG, are associated with disease duration of
Parkinson’s Disease (PD) patients. Material and Methods: 172 PD were included.
PKG measurements, clinical data and disease duration were collected.
Patients were categorized in four disease duration categories (0 - 5 years, 6 - 7
years, 8 - 11 years and ≥12 years). Kruskal-Wallis and Mann-Whitney U tests
were used for statistical analysis. Results: The mean age of the patients is 69.2
years (SD ± 8.13). Disease duration varies between 1 and 28 years. Significant
difference was found between the four disease categories in FS (p = 0.050);
between group 1 - 3, p = 0.005. Conclusions: As expected, FS measured by
PKG increase during disease progression in PD. In advanced disease stages,
FS stabilise, indicating that PKG is the most useful in early and moderate
stages of PD.