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Leal Jr., S.M., Vareechon, C., Cowden, S., Cobb, B.A., Latgé, J.P., Momany, M. and Pearlman, E. (2012) Fungal Antioxidant Pathways Promote Survival against Neutrophils during Infection. The Journal of Clinical Investigation, 122, 2482-2498.
https://doi.org/10.1172/JCI63239

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• TITLE: Proteomic Differences between Azole-Susceptible and -Resistant Aspergillus fumigatus Strains

  AUTHORS: Edith Vermeulen, Sebastien Carpentier, Olaf Kniemeyer, Machteld Sillen, Johan Maertens, Katrien Lagrou

  KEYWORDS: Aspergillus fumigatus, Triazole Resistance, Proteomic, Mass Spectrometry

  JOURNAL NAME: Advances in Microbiology, Vol.8 No.1, January 31, 2018

  ABSTRACT: Background: Azole-resistance is increasingly reported in Aspergillus fumigatus infections. It remains challenging to rapidly assess antifungal susceptibility to initiate the appropriate therapy. The aim of this study was to map the proteomic differences of azole-susceptible and -resistant strains. Methods: Proteomic studies were performed with ultra-performance liquid chromatography tandem mass-spectrometry (UPLC-MS/MS). Results: UPLC-MS/MS detected 7899 peptides, of which 1792 peptides had a significantly different abundance (p A. fumigatus resistance. Conclusions: UPLC-MS/MS provided proof-of-concept that the proteome of azole-resistant A. fumigatus is diverse enough to serve as a diagnostic tool.