TITLE:
Expression of Skin Barrier Protein Filaggrin in Skin Diseases without Atopic Dermatitis
AUTHORS:
Yang Zhang, Chen Tu, Shuang Wang, Shengxiang Xiao
KEYWORDS:
Skin Barrier, Psoriasis, Filaggrin, Atopic Dermatits
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.6 No.1,
January
29,
2018
ABSTRACT: The epidermis represents an essential barrier versus a broad range of
exogenous stimuli. To form a functional epidermis, keratinocytes express
filaggrin which plays a vital role in atopic dermatitis. However the
relationship between filaggrin and other skin diseases remains unknown. In our study we chose
5 different common skin diseases and analyzed the expression of filaggrin in
the skin using immunohistochemistry. Imiquimod (IMQ)-induced mouse model was
used for detecting the filaggrin level and barrier function. The results indicated
that the expression of filaggrin is reduced in psoriasis compared to the other
skin diseases. Furthermore in vivo study
showed that the skin barrier is defected with a decreased expression of
filaggrin in IMQ-induced psoriasis mouse model, which is accompanied with an increased
level of IL-17/IL-23. In conclusion, the defective skin barrier is involved in
the development of psoriasis in human and mice with a reduced expression of
filaggrin which may be regulated by the increased level of IL-17/IL-23 in the
skin.