TITLE:
Retrospective Study of 23 Cases of Psoriasis Association with HIV Infection Observed in the Department of Dermatology-STD in the University Hospital of Donka Conakry Guinea
AUTHORS:
M. Keita, M. M. Soumah, T. M. Tounkara, D. Sylla, B. F. Diané, F. B. Sako, H. Baldé, M. Cissé
KEYWORDS:
Psoriasis, HIV Infection, Epidemiology, Clinical, Therapeutic, Guinea
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.8 No.1,
January
25,
2018
ABSTRACT: Introduction :The
psoriasis is one of the inflammatory dermatoses with unknown etiology, with
chronic evolution having episodic appearance and disappearance. Its prevalence
in HIV patients varied from 2% to 5% in most of the times. Objective of this
study was to describe the demographic, clinical and therapeutic characteristics
of psoriasis patients infected with HIV. Methods: It is
a descriptive retrospective study done from January 2003 to December 2013 based
on the information from the hospital card of hospitalized patients and
outpatients taken care in the department of Dermatology-STD for psoriasis at
the University hospital center in Donka Conakry. We included all the cases of
psoriasis associated with HIV infection diagnosed from clinical and
paraclinical elements. Results: We
recorded 23 (24.73%) cases of psoriasis associated with HIV infection among 93
patients observed for psoriasis in which there are 4 cases of psoriasis vulgaris, 10 cases of erythrodermic psoriasis and 9
cases of arthropathic form among these numbers. We had 7 women and 16 men. The
medium age of our patients was 44.5 ± 12 years [27 - 62 years]. The delayed duration time of consultation varied
from 30 to more than 180 days. The psoriasis was the circumstance of the
discovery of the HIV infection among 55% of cases. The pruritus was the
functional sign which is the most frequent in 20 cases among 23 cases and 71.4% of cases were
accompanied with pain. Family history was found in 7.10% of cases. Anxiety was
the dominant factor cause in 42% and the infection 38%. The cutaneous
alteration was noted in all patients; 92.9% of patients had nails alteration
and intertrigineous association in 78.6% of cases. The clinical forms found were psoriasis vulgaris 4/23 cases, arthropathic psoriasis 9/23 cases,
erythrodermic psoriasis 10/23. More than half (13/23) cases of our patients
were diagnosed stage III of the classification of WHO. The complicated forms like
erythrodermic and arthropathic psoriasis were frequent in patients whose total
CD4 red co-morbidity was tuberculosis (9 cases). The use of traditional
therapeutic means was noted in 50% of cases. The local treatment was based on
dermocorticoid and keratolylic drugs. The general treatment received by all
patients was antiretroviral medication and Methotrexate. Discussion: Our results are of course not representing all the
cases of psoriasis in Guinea but it gives us an idea of the importance of HIV
and psoriasis association and the influence of immunodepression inducted by HIV during the evolution of psoriasis. The demographic, clinical
and therapeutic characteristics described in our patients were near those reported by more authors. Conclusion: HIV-associated psoriasis does not appear to be
familial. Serious clinical forms occur in highly immunocompromised patients.