TITLE:
Evaluation of Cardiovascular Risk Factors in Tunisian Coronary Patients
AUTHORS:
Grira Nadra, Sandesni Rihab, Lamine Ossama, Aboulkassem Sana, Ayoub Manel, El Oudi Mabrouka, Stambouli Najla, Lahidheb Thaker, Haouala Habib, Mazigh Chakib, Aouni Zied
KEYWORDS:
Acute Coronary Syndrome, Cardiovascular Risk Factors, Homocysteine, Methylenetetrahydrofolate Reductase, C677T Polymorphism
JOURNAL NAME:
Open Access Library Journal,
Vol.5 No.1,
January
11,
2018
ABSTRACT: Introduction: Ischemic heart disease ranked among the leading causes of death worldwide. Several biological and genetic risk factors associated with acute coronary syndrome. By addressing the risk factors, it is possible to prevent most of the cardiovascular diseases and contribute to the reduction of complications of acute coronary syndrome. Material and Methods: Our study is a prospective study that was conducted to the main military hospital of instruction of Tunis. Recruitment involved 122 coronary (n = 122) and 705 controls (n = 705) totaling a population of 827 subjects. Data collection concerned socio-demographic characteristics, anthropometric measurements, habits and lifestyle, health status and biological assessment. Results: Our study reported a high prevalence of cardiovascular classic risk factor particularly overweight (62.3%), diabetes (63.1%) and hypertension (50%). In 55% of coronary patients, moderate to intermediate hyperhomocysteinemia was found, but it appears to be an independent risk factor. The results of our study show a significant difference in the genotypic frequencies of the C677T mutation in the MTHFR gene between the two populations, cases and controls. Conclusion: Acute coronary syndromes are the leading cause of sudden death in adults. The evaluation of risk factors after acute coronary syndrome episode is essential for a better management according to the recommendations of learned societies and standards of good practice.