TITLE:
Main Microbial Genres and Its Profile of Resistance and Sensitivity to Antimicrobials Used in the Treatment of Oncological Patients with Febril Neutropenia
AUTHORS:
Hélvecio Cardoso Póvoa, Richard Raphael Borges Tavares Vieira, Elias Sobreira Sathler, Isabela Nardoni Bernardes, Rafael Batista Ferreira, Mário Henrique Couto Lima, Thiago Sande Miguel, Nayrton Kalys Cruz dos Anjos, Lamara Laguardia Valente Rocha, Daniel Almeida da Costa
KEYWORDS:
Febrile Neutropenia Antimicrobial Resistance, Oncologic Patients
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.6 No.1,
January
10,
2018
ABSTRACT: Objective: To determine the main microbial genotypes and their antimicrobial resistance
and susceptibility profile commonly used in the treatment of oncologic patients
with febrile neutropenia, carried out through the review of the clinical
histories of the patients’ medical records at the Hospital do Cancer de Muriaé-Fundacao Cristiano Varella. Methods: Quantitative research, determined the susceptibility profile of
microorganisms in patients with febrile neutropenia from April 2007 to April
2008 by reviewing clinical histories of patients’ medical
records at the referred hospital. Results: Of the total of 8 patients
evaluated with Gram-negative microorganisms, 50% of the patients were female and 50% were male. Of the 18 patients
evaluated with Gram-positive microorganisms 66% were female and 34%
male. Gram-positive bacteria are prevalent and cause around 60% of documented
bacteremias, although Gram-negative bacteria are more common in febrile
neutropenic patientes. Conclusion: Exaggerated use of antimicrobials in
hospitalized patients leads to the suppression of drug-sensitive microorganisms
from the intestinal flora and promotes the persistence and growth of resistant
bacteria. The antibiotic should be used in a curative manner with other
therapeutic measures with the determined bacterial infection.