TITLE:
Clinical Characteristics of Vaginal Discharge Associated Streptococcus pyogenes at General Japanese Hospital
AUTHORS:
Masaaki Minami, Ryoko Sakakibara, Mika Watanabe, Hideo Morita, Naoto Kanemaki, Michio Ohta
KEYWORDS:
Streptococcus pyogenes, Susceptibility, Antimicrobial Resistance, Vaginal Discharge, Clarithromycin
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.6 No.1,
December
29,
2017
ABSTRACT: Streptococcus pyogenes (S. pyogenes) is popular pathogen caused various infectious disease. This study was conducted to find out the recent clinical characteristics of S. pyogenes isolates from vaginal discharge at Japanese hospital. S. pyogenes was identified by standard laboratory procedure. Antimicrobial susceptibility testing was performed by microdilution assay according to CLSI recommendation. Total 61 S. pyogenes were isolated from vaginal discharge. The major age incidence among 0 - 10 years age group was 14 (23%), among 21 - 30 years age group, 7 (11.5%), among 31 - 40 years age group, 13 (21.3%), among 51 - 60 years age group, 8 (13.1%), and among 61 - 70 years age group, 11 (18%). The numbers of ciprofloxacin and clarithromycin no-susceptible S. pyogenes from 0 - 10, 31 - 40, and 61-70 years age group were higher than those from other groups. The numbers of clindamycin and minocycline no susceptible S. pyogenes from 0 - 10, and 21 - 40 years age group were higher than those from other group. Furthermore, our study revealed that clarithromycin was completely ineffective in 21 - 30 years age group (p S. pyogenes because the trend of infectious disease epidemiology is always changing drastically.